Immune system effects

A gastrointestinal flora in balance can enhance the immune health and contributes to and promotes a better general health.

Two trials with L. reuteri Protectis (BioGaia) have shown positive effects on prevention of infectious disease: Supplementation with BioGaia has a significantly positive effect on the incidence of common infections in children in day care and improve work-place healthiness by reducing short term sick-leave caused by respiratory or gastrointestinal infections.

BioGaia Protectis enhancing immune health

  • Interacts with the immune system of the GI tract

  • Modulates immune responses through cytokines and chemokines in tissues distal from the gut

  • Boosting immune responsiveness

  • Maintaining everyday health in children and adults

  • May reduce risk of respiratory allergy and asthma later in life

A gastrointestinal flora in balance contributes to and promotes a better general health.

BioGaia Probiotic Drops and Tablets

Limosilactobacillus reuteri Protectis has been shown to maintain digestive health and function and to keep the body’s natural defence.

BioGaia Dosage recommendations

1 chewable tablet or 5 drops daily

Comparison of two probiotic agents

Effect of a probiotic infant formula on infections in child care centres.

Weizman Z, Asli G, Alsheikh A. (2005) Pediatrics 115:5-9.
Health protection with BioGaia Protectis in children.


L. reuteri significantly reduced

  • days with fever
  • episodes and days with diarrhoea
  • need to consult a doctor and need of antibiotics
  • absence from day care


  • Occurrence of number of febrile episodes and episodes of gastrointestinal infections were statistically less frequent in the probiotic group

  • L. reuteri (BioGaia) had a significantly superior effect compared to B. lactis

  • Significantly fewer doctor visits, fewer use of antibiotics and fewer absent days from day care


  • Prospective, randomized, placebo controlled study

  • 201 healthy children, aged 4–10 months, were studied for 12 weeks in three different groups:

  • They were given formula with L. reuteri ATCC 55730 (BioGaia) or Bifidobacterium lactis Bb-12, or formula without probiotics (control)

Randomised, double blind placebo-controlled study

Increasing workplace healthiness with the probiotic Limosilactobacillus reuteri.

Tubelius et al., Environ Health 4:25 (2005). Health protection by BioGaia in adults.


  • Reduced sick days at home with short term

  • gastro-intestinal or respiratory illness

  • The frequency of sick days of ordinary workdays was 0.9% in the placebo group vs. 0.4% in the L. reuteri group (p<0.01)

  • L. reuteri: <1 sick day /individual and year

  • Placebo: 3 sick days /individual and year


  • Daily supplementation with the probiotic Limosilactobacillus reuteri ATCC 55730 (BioGaia) could reduce the incidence of common infections and thereby reduce short-term sick leave at a major Swedish workplace.

  • Effect pronounced in shift workers


  • Randomised, double blind, placebo-controlled study
  • 181 healthy company employees , received once daily over 3 months to use a probiotic drinking straw containing 10^8 CFU of L. reuteri (Bio- Gaia) or an identical placebo drinking straw, together with at least 100 ml liquid and completed a diary on symptoms of gastrointestinal infection or upper respiratory tract infection (common cold), duration of symptoms and number of days away from work due to such symptoms.
  • L. reuteri (n=94) or placebo (n=87).
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